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Tg(hs799-cre/ERT2,-GFP)405Jlr - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(hs799-cre/ERT2,-GFP)405Jlr
transgene insertion 405, John Rubenstein 		Driver: hs799
Type: Transgenic (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: 799-CreER-IRES-GFP
Molecular description: This transgene contains the human enhancer element hs799, which is flanked on human Chr 7 by the neurexophilin 1 (NXPH1) gene and the human ortholog of the mouse AA545190 long non-coding RNA (lncRNA) gene, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(hs799-cre/ERT2,-GFP)405Jlr activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:288455 Fig. S3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory