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Tg(Pdgfrb-cre/ERT2)6096Rha - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Pdgfrb-cre/ERT2)6096Rha
transgene insertion 6096, Ralf H Adams 		Driver: Pdgfrb
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Pdgfrb(BAC)-CreERT2, PDGFR-betaiCre
Molecular description: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP24-62H17TJ) containing the entire murine platelet-derived growth factor receptor, beta polypeptide (Pdgfrb) gene. This BAC was modified to insert a creER fusion gene (a cre recombinase fused to a human estrogen receptor ligand-binding domain) into the start codon of Pdgfrb to drive expression in mural cells. The other genes on the BAC (Camk2a, Slc6a7, Cdx1, Csf1r, and Hmgxb3) are still present in the construct.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Pdgfrb-cre/ERT2)6096Rha activity also observed in:
hemolymphoid system, limbs
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:333199 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 33 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory