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Tg(Prop1-icre)517Sac - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Prop1-icre)517Sac
transgene insertion 517, Sally A Camper 		Driver: Prop1
Type: Transgenic (Recombinase)
Synonym: Prop1-cre, Tg(Prop1-cre)517Sac, Tg(Prop1-icre)1Sac
Molecular description: A BAC (RP23-479M11) containing the Prop1 gene was modified by inserting a cassette composed of the sequence encoding a mammalian codon usage optimized cre recombinase (icre), the bovine GH polyadenylation signal and an Frt-flanked kanamycin selection marker, into the exon 2 in frame. Flpe excision removed the kanamycin selection marker. The modified BAC was injected into pronuclei of fertilized oocytes to generate transgenic mice. Three lines, 432, 506, and 517 were genereted, and all 3 lines exhibit cre activity throughout the pituitary anterior lobe at 3 weeks of age. Line 517 was used for studies because it best reflected endogenous Prop1 expression.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Prop1-icre)517Sac activity also observed in:
alimentary system, head, nervous system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory