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Agtr1atm1.1(cre)Ekrs - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Agtr1atm1.1(cre)Ekrs
angiotensin II receptor, type 1a; targeted mutation 1.1, Eric Krause 		Driver: Agtr1a
Type: Targeted (Recombinase, Reporter)
Synonym: AT1aR-Cre
Molecular description: A targeting construct was designed to insert a Cre Recombinase gene and a zsGreen (enhanced green fluorescence protein) just upstream of the 3'UTR of the angiotensin II receptor, type 1a (Agtr1a) gene. Viral P2A oligopeptides, from porcine teschovirus-1, were inserted upstream and downstream of the cre gene to enable ribosomal skipping. A frt-flanked neomycin resistance (neo) cassette was placed downstream of the 3'UTR. This construct was electroporated into C57BL/6J embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and the resulting chimeric mice were bred to FLP (FLPo) recombinase expressing mice to delete the neo cassette.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Agtr1atm1.1(cre)Ekrs activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:240544 Fig. 3 J:302597 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory