About   Help   FAQ
Ly6atm2.1(cre/Esr1*)Jmol - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Ly6atm2.1(cre/Esr1*)Jmol
lymphocyte antigen 6 family member A; targeted mutation 2.1, Jeffery D Molkentin 		Driver: Ly6a
Type: Targeted (Inducible, Null/knockout, Recombinase)
Inducer: tamoxifen
Synonym: Ly6aMerCreMer
Molecular description: A cDNA encoding a MerCreMer fusion protein and an FRT-flanked neomycin cassette were recombined in-frame with the Ly6a ATG start codon (exon 2) via homologous recombination in embryonic stem (ES) cells. The MerCreMer double fusion protein incorporates a cre recombinase cDNA sequence flanked by mutated murine estrogen receptor (mer) ligand binding domains (amino acids 281-599, G525R). Resultant mice were crossed with Flpe mice to delete the neomycin cassette. Expression of Ly6a is eliminated in the targeted allele.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Ly6atm2.1(cre/Esr1*)Jmol activity also observed in:
alimentary system, cardiovascular system, hemolymphoid system, liver & biliary system, respiratory system
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory