Cdh10<tm1.1(cre/ERT2)Jrs> - Nervous System Recombinase Activity Detail MGI Mouse

Cdh10^{tm1.1(cre/ERT2)Jrs} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Cdh10^{tm1.1(cre/ERT2)Jrs}
cadherin 10; targeted mutation 1.1, Joshua R Sanes

Driver: Cdh10
Type: Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Synonym:

Cdh10^CreER

Molecular description:

The targeting vector contained (from 5' to 3') a cDNA sequence encoding the CreER fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) with N-terminal 6xMyc tag, followed by an FRT-flanked SV40-neo selection cassette. A 6XMyc-CreERT was inserted into the first coding exon (exon 2) of the cadherin-10 (Cdh10) gene by homologous recombination in mouse. Flp-mediated recombination removed the FRT-flanked neo cassette. Knockout of the cadherin-10 protein was confirmed biochemically and immunohistochemically.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Cdh10^{tm1.1(cre/ERT2)Jrs} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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