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Allele Information
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Allele:
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Fgf18tm2.2(cre/ERT2)Dor
fibroblast growth factor 18;
targeted mutation 2.2, David M Ornitz
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Driver: Fgf18
Type: Targeted
(Inducible, Null/knockout, Recombinase, Reporter)
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Inducer:
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tamoxifen
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Synonym:
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Fgf18CreERT2
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Molecular description:
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A multifunctional targeting vector inserted a splice acceptor (SA)-eGFP:CreERT2 fusion gene into the intron located between Fgf18 exons 1B and 1C along with a PGK-neo selection cassette. Additional Frt and LoxP recombination sites were placed in the targeted allele to allow the generation of two independent alleles by crossing the parental mouse line to either a germline expressed FLP recombinase or a germline expressed Cre recombinase mouse. This generated a tamoxifen inducible eGFP:CreERT2 allele driven by the endogenous Fgf18 promoter (Fgf18CreERT2) that can be used for lineage tracing. The Fgf18CreERT2 allele has exon 1C deleted and is predicted to behave as a functional null allele.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Fgf18tm2.2(cre/ERT2)Dor activity also observed in:
alimentary system,
cardiovascular system,
embryo-other,
extraembryonic component,
head,
hemolymphoid system,
limbs,
liver & biliary system,
nervous system,
renal & urinary system,
respiratory system,
skeletal system,
tail
(less)
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Tissue Information
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Mesenchyme
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Other recombinase alleles with activity in Mesenchyme tissues:
7630403G23RikTg(Th-cre)1Tmd,
Acanem2(dre)Smoc,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Alx3em1(cre/ERT2)Lanyu,
Amhr2tm3(cre)Bhr,
Atoh8tm1(EGFP/cre)Gasa,
Bmp7tm6(cre)Rob,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cfap126tm1.1(icre)Heli,
Cldn6tm1(cre/ERT2)Dam,
Col10a1tm2.1(cre)Ksec,
Crhtm1(cre)Zjh,
Ddx4em1(icre)Jobo,
Dmbx1tm3(cre)Aoh,
E2f1Tg(Wnt1-cre)2Sor,
Edil3Tg(Sox2-cre)1Amc,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
Eomestm4.1(icre)Rob,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxa2tm3.1(icre)Heli,
Foxd1tm1(GFP/cre)Amc,
Foxg1tm1(cre)Skm,
Gad2tm2(cre)Zjh,
Gli1tm3(cre/ERT2)Alj,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sortm1(FLP1)Dym,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hand2em1(dre)Pjen,
HhatTg(TFAP2A-cre)1Will,
Hlfem1(cre/ERT2)Smoc,
Hlfem2(cre/ERT2)Suda,
Hnf4atm1(cre)Sdv,
Hoxa3tm1(cre)Moon,
Hoxb1tm1(cre)Og,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Krt19tm1(cre)Mmt,
Lgr6tm2.1(cre/ERT2)Cle,
Lhx1tm1.1(icre)Rob,
Lmx1btm2(cre/ERT2)Rjo,
Ltftm1(icre)Tdku,
Mecomem1(cre/ERT2)Suda,
Mecomtm4.1(cre/ERT2)Aspe,
Megf6em3(cre)Zzhg,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Nkx1-2tm2296.1(cre/ERT2)Arte,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm1(cre)Wez,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Npr3em1(cre/ERT2)Bzsh,
Nrg1em2(cre/ERT2)Bzsh,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pax9tm1.1(cre)Sbam,
Pdgfctm2.1(cre/ERT2)Hdin,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm1.1(flpo)Leol,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Sall4tm1.1(EGFP/cre/ERT2)Ykawa,
Scxtm1.1(cre)Shuk,
Shhtm1(EGFP/cre)Cjt,
Shroom3Gt(ROSA53)Sor,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Smoc2tm1(cre/ERT2)Cle,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx1tm1.1(cre/ERT2)Zzhg,
Tbx5tm1.1(cre/ERT2)Bbr,
Tg(Acan-cre/ERT2,-luc)1Gbg,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(ACTC1-cre)1Miwa,
Tg(Adipoq-cre)1Evdr,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)#Ykub,
Tg(Cdx1-cre)23Kem,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(Cited1-cre/ERT2,-EGFP)1Mdca,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1And,
Tg(Col10a1-cre)1465Vdm,
Tg(Col10a1-cre)1466Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col10a1-cre)#Ksec,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp39a1-cre)1Aibs,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre/ERT2)#Mpac,
Tg(Dll1-cre)1Gos,
Tg(Dll1-cre)33Dchp,
Tg(Dll4-cre)#Xia,
Tg(dlx5a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Etv2-cre)15508Djg,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Fev-cre)FF9Pasq,
Tg(Foxa3-cre)1Khk,
Tg(Foxl1-cre)1Khk,
Tg(Frzb-cre)1Tylz,
Tg(GATA5-cre)1Krc,
Tg(Gdf5-cre,-ALPP)1Kng,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hand2-cre)7-1Clou,
Tg(Hes7-cre)1Kag,
Tg(Hoxa2-cre)1Dym,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mnx1-cre/ERT2)8Rbro,
Tg(Mpz-cre)1Brn,
Tg(Mpz-cre)94Imeg,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh6-cre)2182Mds,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre)1Wmz,
Tg(Nkx2-1-cre)2Sand,
Tg(NKX2-5-cre)#Kyuhl,
Tg(NKX2-5*-cre)#Kyuhl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Nrp2-cre/ERT2,-Kikume)1Qsch,
Tg(Osr1-cre)4Mrt,
Tg(Pax2-cre)10Shwl,
Tg(Pax3-cre)1Joe,
Tg(Pax3-cre)2Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(POU3F4-cre)M51Cren,
Tg(Pou4f3-cre)1Devet,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Mpac,
Tg(Prg4-cre)#Mkaz,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Rr437-cre)#Hmd,
Tg(Rr456-cre/Esr1*)7Hmd,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(Rxfp2-cre)1Aia,
Tg(Rxfp2-cre)5Aia,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Six1-cre)2Kwk,
Tg(Smad7-cre)1Sjc,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Sox10-cre)507Mcln,
Tg(Sox10-ERT2/cre/ERT2)17Sor,
Tg(Sox10-icre/ERT2)388Wdr,
Tg(Sox2-flpo)#Mhem,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Stab2-icre)1.2Cger,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx1-cre)1Joe,
Tg(Tbx4-cre)6Kras,
Tg(Tbx4-cre/ERT2)#Kras,
Tg(Tbx6-cre)#Rsam,
Tg(T-cre)1Gos,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Ymor,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(Wnt1-cre/ERT)1Alj,
Tg(Wt1-cre)1Jbeb,
Tg(Wt1-cre)#Jbeb,
Ttm1(cre/ERT2)Hssk,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor,
Vimem1(cre/ERT2)Bzsh,
Wnt6tm1(cre)Mrc,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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J:279323
Fig. 4
J:279323
Fig. 5
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Recombinase Activity
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References
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