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Rpe65tm1.1(cre/ERT2)Kser - Head
Recombinase Activity Detail
Allele Information
Allele:
Rpe65tm1.1(cre/ERT2)Kser
retinal pigment epithelium 65; targeted mutation 1.1, Philip Kiser 		Driver: Rpe65
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym:
Molecular description: The targeting construct was designed to fuse a P2A self-cleaving peptide sequence and a cre/ERT2 sequence in frame at the 3' of exon 14 of the retinal pigment epithelium 65 (Rpe65) gene. The cre-ERT2 fusion gene contains a Cre recombinase fused to a human estrogen receptor ligand binding domain. A frt-flanked neomycin resistance (neo) cassette was placed immediately after the non-coding exon 15. This construct was electroporated into C57BL/6 FLP-derived iTL BF1 embryonic stem (ES) cells. The Neo cassette in the targeting sequence was removed during ES clone expansion.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Rpe65tm1.1(cre/ERT2)Kser activity also observed in:
sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:310003 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory