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Lbhd2em1(cre/ERT2)Fuki - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Lbhd2em1(cre/ERT2)Fuki
LBH domain containing 2; endonuclease-mediated mutation 1, Izumi Fukunaga 		Driver: Lbhd2
Type: Endonuclease-mediated (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Lbhd2-IRES-CreERT2
Molecular description: Using CRISPR/cas9 technology an IRES enhancer sequence, a CreER(T2) fusion gene, and a rabbit globin polyadenylation (rGpA) termination sequence were inserted immediately downstream of the LBH domain containing 2 locus of the Lbhd2 gene on chromosome 12. The construct was electroporated into C57BL/6JJcl-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and chimeric mice were bred with C57BL/6JJcl for germline transmission.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Lbhd2em1(cre/ERT2)Fuki activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:315131 Fig. 11 J:315131 Fig. 12 J:315131 Fig. 7 J:315131 Fig. 8Fig J:315131 Fig. 9
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory