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Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas Vollrath 		Driver: BEST1
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Rosa26BEST1-CreERT2
Molecular description: The allele was created to have the human BEST1 promoter/enhancer regions directing the expression of a CreER(T2) fusion gene. The targeting vector contained, from 5' to 3', the human BEST1 promoter (nucleotides -585 to +38), followed by a CreER(T2) fusion gene, and an SV40 a polyA cassette. The plasmid was pronuclear injected into C57BL/6J(attPx3) zygotes along with phiC31 integrase mRNA. The resulting founder mice were bred with C57BL/6J for germline transmission.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold activity also observed in:
head, sensory organs
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory