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Cxcr4tm1.1(cre/ERT2)Stum - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Cxcr4tm1.1(cre/ERT2)Stum
C-X-C motif chemokine receptor 4; targeted mutation 1.1, Ralf Stumm 		Driver: Cxcr4
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Cxcr4CreER, Cxcr4CreER(T2)-IRES-eGFP
Molecular description: The targeting vector consisting of fragments of 2.9 kb, 3.8 kb and 3.3 kb in size containing the distal promoter sequence, the sequence upstream of exon 1, and the sequence downstream of exon 1, respectively, were used to insert a CreER(T2)-IRES-EGFP cassette and an FRT-flanked neomycin cassette in the 5 end of the 3.3-kb fragment. The linearized construct was electroporated into C57BL/6J mouse ES cells. The neomycin cassette was removed by breeding with C57BL/6J mice expressing Flp-recombinase. With CreER inserted into exon 1, Cxcr4CreER does not produce functional Cxcr4 and homozygous mice bearing this allele are fully deficient in Cxcr4, as verified by immunohistochemistry.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Cxcr4tm1.1(cre/ERT2)Stum activity also observed in:
head, hemolymphoid system, mouse-other
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory