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Irs4tm1.1(cre)Dolsn - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Irs4tm1.1(cre)Dolsn
insulin receptor substrate 4; targeted mutation 1.1, David P Olson 		Driver: Irs4
Type: Targeted (Recombinase)
Synonym: IRS4-iCre
Molecular description: Using a BAC recombineering method, a targeting construct containing an insertion of an Frt-flanked neomycin selection cassette followed by an internal ribosomal entry (tires) sequence fused to a Cre recombinase transgene (iCre) between the STOP codon and the polyadenylation of the Irs4 gene. This construct was used to isolate a targeting plasmid with the neo-iCre cassette with upstream and downstream Crh homology arms. ES cells were targeted and used for blastocyst injection. Chimeras were bred for germline transmission. The selection marker was excised by breeding to Flp deleter animals.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Irs4tm1.1(cre)Dolsn activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:299851 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory