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Cdkn2atm1(cre/ERT2)Mkt - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Cdkn2atm1(cre/ERT2)Mkt
cyclin dependent kinase inhibitor 2A; targeted mutation 1, Makoto Nakanishi 		Driver: Cdkn2a
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: p16-CreERT2, p16Ink4a-CreERT2neo
Molecular description: The exon 1 alpha of the Cdkn2a gene was replaced with a translation start site, a CreERT2 expression cassette and a neo cassette. The retained neo-resistant gene markedly resulted in higher labeling efficacy at this locus presumably due to the fact that a retained neo-resistant cassette can act as a local enhancer to augment reporter expression without compromising tissue reporter fidelity.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Cdkn2atm1(cre/ERT2)Mkt activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory