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Tg(Runx1/Hspa1a-cre/ERT2)#Itoy - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy
transgene insertion, Yoshiaki Ito 		Driver: Runx1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: eR1-CreERT2, eRx1-CreERT
Molecular description: The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of cre/ERT2. More than 10 founder lines were generated. The line TG(5-2) with higher copy number and TG(3-7) with lower copy number used for studies. Although the former had higher Cre recombinase activity than the latter, the results obtained using these lines were qualitatively indistinguishable. The pound symbol (#) is used when no line is specified and/or lines are pooled.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Runx1/Hspa1a-cre/ERT2)#Itoy activity also observed in:
alimentary system, cardiovascular system, liver & biliary system, mesenchyme, mouse-other, skeletal system
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Images
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J:328986 Fig. S4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory