Atoh1<em1(flpo)Hlai> - Nervous System Recombinase Activity Detail MGI Mouse

Atoh1^{em1(flpo)Hlai} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Atoh1^{em1(flpo)Hlai}
atonal bHLH transcription factor 1; endonuclease-mediated mutation 1, Helen C Lai

Driver: Atoh1
Type: Endonuclease-mediated (Recombinase)

Synonym:

Atoh1^P2A-FLPo

Molecular description:

CRISPR/cas9 genome editing is used to insert a P2A, a FlpO recombinase gene after the last amino acid codon and before the stop codon of Atoh1. The cassette contained a minor mutation at the end of FLPo (the last isoleucine amino acid was changed to a serine), which could have occurred possibly because of an imprecise DNA repair event. But, this amino acid change did not affect the enzymatic function of FLPo.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Images

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J:308450 Fig. 1

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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