Pdgfra<tm1.1(flpo)Leol> - Nervous System Recombinase Activity Detail MGI Mouse

Pdgfra^{tm1.1(flpo)Leol} - Nervous System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Pdgfra^{tm1.1(flpo)Leol}
platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Lorin E Olson

Driver: Pdgfra
Type: Targeted (Constitutively active, Recombinase)

Synonym:

aR^deltaK.Flp, Pdgfra^deltaK.Flp

Molecular description:

The targeting cassette consisting of a SA.lox.Neo/Stop.lox-PDGFRaK.T2A.Flp cassette replaced the exons 2-4 of the endogenous Pdgfra gene. The PDGFRaK is a mouse Pdgfra gene cDNA with a point mutation (D842V) renders it constitutively active. Cre-mediated recombination removed lox.Neo/Stop.lox cassette from Pdgfra^{tm1(flpo)Leol} enabling the expression of the constitutively active Pdgfra gene with a point mutation (D842V) and the flpo recombinase.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Pdgfra^{tm1.1(flpo)Leol} activity also observed in:
embryo-other, head, mesenchyme

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

1 reference(s)

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