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Tg(Gnrh1-icre/ERT2)9Jde - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gnrh1-icre/ERT2)9Jde
transgene insertion 9, Jan Deussing 		Driver: Gnrh1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: GnRH-CreERt2
Molecular description: A 208kb BAC containing the mouse Gnrh1 locus (140 kb upstream and 50 kb downstream of the ATG start codon of the Gnrh1 gene) was used to construct a minigene consisting of the fusion protein of modified estrogen receptor alpha ligand-binding protein and a codon-improved Cre recombinase followed by the polyA signal of the human growth hormone gene (hgh pA) and the Frt-flanked neoR (ERt2iCre.FrtNeoRFrt) inserted into exon 2 of the gene downstream of ATG start codon. After removal of the selection marker, the modified BAC DNA was purified and was microinjected into fertilized pronuclei to generate transgenic animals. Eleven transgenic founders were identified. Nine founders transmitted the gene to the offspring. One line (line # 9) was selected, based on its specificity and inducibility of Cre expression, for experiments.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gnrh1-icre/ERT2)9Jde activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:288904 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory