About   Help   FAQ
Tg(Mnx1-cre/ERT2)8Rbro - Limbs
Recombinase Activity Detail
Allele Information
Allele:
Tg(Mnx1-cre/ERT2)8Rbro
transgene insertion 8, Robert M Brownstone 		Driver: Mnx1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Hb9::CreERT2
Molecular description: The bacterial artificial chromosome (BAC) clone RP24-351I23 containing the mouse Mnx1 (Hb9) gene was modified using recombineering bacterial strain to introduce the cre/ERT2-BGH polyA and Frt-Zeo-Frt selection cassette into the exon 1 replacing the Mnx1 coding region. The Frt-Zeo-Frt cassette is retained in the transgene but lacks a eukaryotic promoter. Three founder lines (4, 8, and 10) were generated. Line 10 gave low-level inducible activity and was terminated. Line 4 and Line 8 displayed similar inducible recombination activity in the desired cell populations and were maintained. Lines 4 and 8 were indistinguishable, and line 8 was used for the majority of studies described.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Mnx1-cre/ERT2)8Rbro activity also observed in:
alimentary system, head, mesenchyme, nervous system, skeletal system
Tissue Information
Limbs Other recombinase alleles with activity in Limbs tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:309433 Fig. 1 J:309433 Fig. 2
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory