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Tg(Mnx1-cre/ERT2)8Rbro - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Mnx1-cre/ERT2)8Rbro
transgene insertion 8, Robert M Brownstone 		Driver: Mnx1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Hb9::CreERT2
Molecular description: The bacterial artificial chromosome (BAC) clone RP24-351I23 containing the mouse Mnx1 (Hb9) gene was modified using recombineering bacterial strain to introduce the cre/ERT2-BGH polyA and Frt-Zeo-Frt selection cassette into the exon 1 replacing the Mnx1 coding region. The Frt-Zeo-Frt cassette is retained in the transgene but lacks a eukaryotic promoter. Three founder lines (4, 8, and 10) were generated. Line 10 gave low-level inducible activity and was terminated. Line 4 and Line 8 displayed similar inducible recombination activity in the desired cell populations and were maintained. Lines 4 and 8 were indistinguishable, and line 8 was used for the majority of studies described.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Mnx1-cre/ERT2)8Rbro activity also observed in:
alimentary system, head, limbs, mesenchyme, nervous system
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:309433 Fig. 1 J:309433 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory