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Tg(Mchr1-cre/ERT2)3Nbe - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Mchr1-cre/ERT2)3Nbe
transgene insertion 3, Nicolas F Berbari 		Driver: Mchr1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Mchr1-CreER
Molecular description: A cre/ERT2 expression sequence was inserted downstream of the Mchr1 promoter on the RP23-202N16 BAC via homologous recombination/BAC recombineering; this replaced nucleotides 4-41 from exon 1 and was designed to disable transcription/translation of the Mchr1 protein from the BAC Mchr1 locus. An frt-flanked kanamycin selection cassette used during homologous recombination/BAC recombineering was removed by transient FLP plasmid injection. The resulting Mchr1-cre/ERT2 BAC transgene was purified for subsequent male pronuclear injection to establish transgenic founder animals. Two lines 2 and 3 were generated with similar expression patterns. .
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Mchr1-cre/ERT2)3Nbe activity also observed in:
endocrine system, head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:266416 Fig. 1 J:266416 Fig. 2 J:266416 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory