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Tg(Ins1-cre,-DsRed*T3)#Caoy - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ins1-cre,-DsRed*T3)#Caoy
transgene insertion, Yanan Cao 		Driver: Ins1
Type: Transgenic (Recombinase, Reporter)
Synonym: Ins1-Cre-Dsred
Molecular description: The transgene consists of an 8.5-kb fragment of mouse Ins1 promoter (Ins1; nucleotides -8.5 kb to +12 bp relative to the transcriptional start site), a nuclear location signal fused to the Cre gene fragment, an internal ribosome entry site (IRES) sequence, and a Dsred.T3 cDNA fragment followed by a polyadenylation signal. Seven lines (1-7) were generated with similar expression patterns. The pound symbol (#) is used when no line is specified and/or lines are pooled. Cre expression in different organs was examined by RT-PCR with RNA extracted from pancreatic islets, brain, liver, fat, skeletal muscle, spleen, lungs, small intestine, large intestine, kidney, heart, testes, stomach, and hypothalamus. The results showed the negligible Cre expression in tissues other than islets.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ins1-cre,-DsRed*T3)#Caoy activity also observed in:
alimentary system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory