Nkx2-5<tm1.1(cre/ERT2)Rard> - Head Recombinase Activity Detail MGI Mouse

Nkx2-5^{tm1.1(cre/ERT2)Rard} - Head
Recombinase Activity Detail

Allele Information | Images | Recombinase Activity | References

Allele Information

Allele:

Nkx2-5^{tm1.1(cre/ERT2)Rard}
NK2 homeobox 5; targeted mutation 1.1, Reza Ardehali

Driver: Nkx2-5
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Nkx2-5/CreER

Molecular description:

Using homologous recombination in ES cells an internal ribosome entry site (IRES) linked to the gene encoding a nuclear-localizing recombinase cre fused to ERT2 and a hygromycin resistance gene cassette (pgk-HYGROpA) flanked by yeast flp recombinase target (frt) sites was inserted into the 3' UTR of the endogenous locus. pgk-HYGRO-pA cassette was removed by crossing to Flp recombinase gene expressing mice.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Nkx2-5^{tm1.1(cre/ERT2)Rard} activity also observed in:
cardiovascular system

Images

Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images

J:243421 Fig. 3

Recombinase Activity

Click heading to re-sort table.

Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24