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Tg(Ins2-tTA,tetO-cre)1Ctlh - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ins2-tTA,tetO-cre)1Ctlh
transgene insertion 1, Carol T L Huang 		Driver: Ins2
Type: Transgenic (Inducible, Recombinase, Transactivator)
Inducer: doxycycline/tetracycline
Synonym: RIP-tTA/tetO7-Cre
Molecular description: A 3.5 Kb fragment from a plasmid carrying a rat insulin Ins2-tTA cassette and a 3.9 Kb fragment from a plasmid carrying TetO7 cloned upstream of Cre-encoding DNA were co-injected into fertilized oocytes to produce double-transgenic mice. Five lines were generated and one line showed cre activity doxycycline dependant manner, on with the absence and off with the presence of doxycycline, in islet cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ins2-tTA,tetO-cre)1Ctlh activity also observed in:
alimentary system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:244123 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory