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Allele Information
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Allele:
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Synonym:
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CNkx2.5-SHFnm-cre
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Molecular description:
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A mutated version of the chicken second heart field (SHF) NK2 homeobox 5 enhancer (cardiac activating region 3 (CAR3); nucleotides 976-3047 after transcriptional start site), where the Nkx2-5-binding consensus sequence in the BMP response element (BMPRE) was mutated from TCTGAGTG to TCTGCGAG, was used to drive the expression of the cre recombinase gene. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(NKX2-5*-cre)#Kyuhl activity also observed in:
alimentary system,
branchial arches,
cardiovascular system
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Tissue Information
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Mesenchyme
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Other recombinase alleles with activity in Mesenchyme tissues:
7630403G23RikTg(Th-cre)1Tmd,
Acanem2(dre)Smoc,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Alx3em1(cre/ERT2)Lanyu,
Amhr2tm3(cre)Bhr,
Atoh8tm1(EGFP/cre)Gasa,
Bmp7tm6(cre)Rob,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cfap126tm1.1(icre)Heli,
Cldn6tm1(cre/ERT2)Dam,
Col10a1tm2.1(cre)Ksec,
Crhtm1(cre)Zjh,
Ddx4em1(icre)Jobo,
Dmbx1tm3(cre)Aoh,
E2f1Tg(Wnt1-cre)2Sor,
Edil3Tg(Sox2-cre)1Amc,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
Eomestm4.1(icre)Rob,
Fgf18tm2.2(cre/ERT2)Dor,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxa2tm3.1(icre)Heli,
Foxd1tm1(GFP/cre)Amc,
Foxg1tm1(cre)Skm,
Gad2tm2(cre)Zjh,
Gli1tm3(cre/ERT2)Alj,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sortm1(FLP1)Dym,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hand2em1(dre)Pjen,
HhatTg(TFAP2A-cre)1Will,
Hlfem1(cre/ERT2)Smoc,
Hlfem2(cre/ERT2)Suda,
Hnf4atm1(cre)Sdv,
Hoxa3tm1(cre)Moon,
Hoxb1tm1(cre)Og,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Krt19tm1(cre)Mmt,
Lgr6tm2.1(cre/ERT2)Cle,
Lhx1tm1.1(icre)Rob,
Lmx1btm2(cre/ERT2)Rjo,
Ltftm1(icre)Tdku,
Mecomem1(cre/ERT2)Suda,
Mecomtm4.1(cre/ERT2)Aspe,
Megf6em3(cre)Zzhg,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Nkx1-2tm2296.1(cre/ERT2)Arte,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm1(cre)Wez,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Npr3em1(cre/ERT2)Bzsh,
Nrg1em2(cre/ERT2)Bzsh,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pax9tm1.1(cre)Sbam,
Pdgfctm2.1(cre/ERT2)Hdin,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm1.1(flpo)Leol,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Sall4tm1.1(EGFP/cre/ERT2)Ykawa,
Scxtm1.1(cre)Shuk,
Shhtm1(EGFP/cre)Cjt,
Shroom3Gt(ROSA53)Sor,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Smoc2tm1(cre/ERT2)Cle,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx1tm1.1(cre/ERT2)Zzhg,
Tbx5tm1.1(cre/ERT2)Bbr,
Tg(Acan-cre/ERT2,-luc)1Gbg,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(ACTC1-cre)1Miwa,
Tg(Adipoq-cre)1Evdr,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)#Ykub,
Tg(Cdx1-cre)23Kem,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(Cited1-cre/ERT2,-EGFP)1Mdca,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1And,
Tg(Col10a1-cre)1465Vdm,
Tg(Col10a1-cre)1466Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col10a1-cre)#Ksec,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp39a1-cre)1Aibs,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre/ERT2)#Mpac,
Tg(Dll1-cre)1Gos,
Tg(Dll1-cre)33Dchp,
Tg(Dll4-cre)#Xia,
Tg(dlx5a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Etv2-cre)15508Djg,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Fev-cre)FF9Pasq,
Tg(Foxa3-cre)1Khk,
Tg(Foxl1-cre)1Khk,
Tg(Frzb-cre)1Tylz,
Tg(GATA5-cre)1Krc,
Tg(Gdf5-cre,-ALPP)1Kng,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hand2-cre)7-1Clou,
Tg(Hes7-cre)1Kag,
Tg(Hoxa2-cre)1Dym,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mnx1-cre/ERT2)8Rbro,
Tg(Mpz-cre)1Brn,
Tg(Mpz-cre)94Imeg,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh6-cre)2182Mds,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre)1Wmz,
Tg(Nkx2-1-cre)2Sand,
Tg(NKX2-5-cre)#Kyuhl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Nrp2-cre/ERT2,-Kikume)1Qsch,
Tg(Osr1-cre)4Mrt,
Tg(Pax2-cre)10Shwl,
Tg(Pax3-cre)1Joe,
Tg(Pax3-cre)2Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(POU3F4-cre)M51Cren,
Tg(Pou4f3-cre)1Devet,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Mpac,
Tg(Prg4-cre)#Mkaz,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Rr437-cre)#Hmd,
Tg(Rr456-cre/Esr1*)7Hmd,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(Rxfp2-cre)1Aia,
Tg(Rxfp2-cre)5Aia,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Six1-cre)2Kwk,
Tg(Smad7-cre)1Sjc,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Sox10-cre)507Mcln,
Tg(Sox10-ERT2/cre/ERT2)17Sor,
Tg(Sox10-icre/ERT2)388Wdr,
Tg(Sox2-flpo)#Mhem,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Stab2-icre)1.2Cger,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx1-cre)1Joe,
Tg(Tbx4-cre)6Kras,
Tg(Tbx4-cre/ERT2)#Kras,
Tg(Tbx6-cre)#Rsam,
Tg(T-cre)1Gos,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Ymor,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(Wnt1-cre/ERT)1Alj,
Tg(Wt1-cre)1Jbeb,
Tg(Wt1-cre)#Jbeb,
Ttm1(cre/ERT2)Hssk,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor,
Vimem1(cre/ERT2)Bzsh,
Wnt6tm1(cre)Mrc,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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J:192448
Fig. 2
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Recombinase Activity
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Assays
Genotypic Background
Result Notes
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References
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