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Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu
intergenic site 2; targeted mutation 1, Ming Xu
Driver: Cdkn1a
Type: Targeted (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: p21-Cre
Molecular description: Site-specific PhiC31 integrase-mediated transgenesis is used to insert a 3,225-bp mouse Cdkn1a (p21) promoter fragment followed by a bicistronic message consisting of the coding sequence for Cre fused to an ERT2 domain, an IRES followed by an ORF coding for enhanced GFP into the intergenic site 2 locus (Hipp11). This construct was microinjected into the pronucleus of recipient zygotes containing attP sites in the Hipp11 locus. Site-specific recombination occurred between the attB sites in the plasmid and attP sites in the H11 genomic locus. Positive embryonic stem cell clones were then implanted into C57BL/6 females.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu activity also observed in:
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory