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Egr1tm1.1(cre/ERT2)Jglt - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Egr1tm1.1(cre/ERT2)Jglt
early growth response 1; targeted mutation 1.1, Jean-Antoine Girault 		Driver: Egr1
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Egr1-CreERT2, Tg(Egr1-CreERT2)
Molecular description: A targeting vector consisting of a Cre/ERT2 cassette and a neomycin resistance gene flanked by FRT sequences were inserted into the transcription start site of the Egr1 gene in a bacterial artificial chromosome (BAC, clone RP23-70M6) that contained the entire mouse Egr1 gene with 95 kb 5 upstream and 86 kb downstream regions was used for homologous recombination in the ES cells. After selection and cloning of the ES cells, the neomycin resistance gene was removed by flipase and the resulting transgenic ES cells were injected into agouti blastocysts to obtain chimeric mice. Two lines (U62-2 and U62-7) were obtained, and U62-2 line was established and used for the studies.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Egr1tm1.1(cre/ERT2)Jglt activity also observed in:
head, nervous system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory