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Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Tomoji Mashimo 		Driver: CAG
Type: Endonuclease-mediated (Inducible, Recombinase)
Inducer: blue light exposure
Synonym: PA-Cre KI
Molecular description: A 7.0 kb PA-Cre expression plasmid under the control of the CAG promoter was introduced at the Gt(ROSA)26Sor locus using the CRISPR/Cas9 system. PA-Cre consists of a split Cre (59/60) with each fragment complemented with nMag or pMag (respectively) and a nuclear localization sequence (NLS) (CreN59-nMag-NLS and NLS-pMag-CreC60), separated by P2A self-cleaving peptide sequence (2A). The nMag and pMag are part of Magnets protein derived from the fragments of photoreceptor gene product Vivid (VVD) from a filamentous fungi Neurospora crassa.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory