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Tg(Flt1-cre/ERT2)1Tmak - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Flt1-cre/ERT2)1Tmak
transgene insertion 1, Taija Makinen 		Driver: Flt1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Flt1-CreERT2, Vegfr1-CreERT2
Molecular description: A BAC (B6Ng01-247E8) carrying the mouse Flt1 gene was used to generate a transgene by replacing the coding sequence in exon 1 as well as the splice donor site at the junction between exon 1 and intron 1 (50 bp) with a cassette containing the open reading frame for CreERT2 and the Flt1 3' untranslated region. A polyadenylation signal (human growth hormone polyadenylation signal) was inserted 3' of the Flt1 3'UTR sequence. Two independent founder lines were generated, of which one (line 1) showed efficient Cre-mediated recombination and was used for further analyses.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Flt1-cre/ERT2)1Tmak activity also observed in:
alimentary system, cardiovascular system, cavities & their linings, integumental system, sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:341130 Fig. S1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory