Prtn3<tm1.1(cre/ERT2,CD4*)Wkas> - Skeletal System Recombinase Activity Detail MGI Mouse

Prtn3^{tm1.1(cre/ERT2,CD4*)Wkas} - Skeletal System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Prtn3^{tm1.1(cre/ERT2,CD4*)Wkas}
proteinase 3; targeted mutation 1.1, Wolfgang Kastenmuller

Driver: Prtn3
Type: Targeted (Inducible, Inserted expressed sequence, Recombinase)

Inducer:

tamoxifen

Synonym:

Prtn3^CreERT2-hCD4

Molecular description:

An IRES-CreERT2-IRES-humanCD4-FRT-neo-FRT construct was inserted into the 5th exon of the endogenous Prtn3 gene after the endogenous stop codon. The Neomycin cassette used for selection was then removed by the flippase enzyme. The human CD4 coding sequence used in the construct lacks the C-terminal 33 amino acids and contains the F43I mutation, generating a mutated and truncated protein that precludes signaling and association with MHCII.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Prtn3^{tm1.1(cre/ERT2,CD4*)Wkas} activity also observed in:
hemolymphoid system

Tissue Information

Skeletal System

Other recombinase alleles with activity in Skeletal System tissues:

Acan^{tm1(cre/ERT2)Crm}, Agrp^tm1(cre)Lowl, Alpl^tm1(cre)Nagy, Alx3^{em1(cre/ERT2)Lanyu} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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