Sequence Detail

ID/Version

B1AWN6 A0A0J9YTW6 (UniProt | EBI)

Last sequence update: 2008-04-08
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Sodium channel protein type 2 subunit alpha {ECO:0000305};AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.2;

Provider

SWISS-PROT

Sequence

Polypeptide 2006 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scn2a	sodium channel, voltage-gated, type II, alpha	49	104	3	17

Sequence references in MGI

J:76457 Planells-Cases R, et al., Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J. 2000 Jun;78(6):2878-91
J:108884 Kearney JA, et al., A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience. 2001;102(2):307-17
J:240934 Thompson CH, et al., CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1696-1701
J:264736 Middleton SJ, et al., Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene. Nat Neurosci. 2018 Jul;21(7):996-1003
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89