ID/Version |
|
||||||||||||||
Sequence description from provider |
RecName: Full=Stalled ribosome sensor GCN1 {ECO:0000305};AltName: Full=GCN1 eIF-2-alpha kinase activator homolog {ECO:0000250|UniProtKB:Q92616};AltName: Full=GCN1-like protein 1 {ECO:0000312|MGI:MGI:2444248};AltName: Full=General control of amino-acid syn | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
2671
aa
|
||||||||||||||
Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
|
||||||||||||||
Sequence references in MGI |
J:100824
Pereira CM, et al., IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem. 2005 Aug 5;280(31):28316-23
J:197824 Roffe M, et al., IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem. 2013 Apr 12;288(15):10860-9 J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7 J:227376 Waller T, et al., Evidence that Yih1 resides in a complex with ribosomes. FEBS J. 2012 May;279(10):1761-76 J:287528 Yamazaki H, et al., Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLoS Genet. 2020 Apr;16(4):e1008693 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:337230 Liu J, et al., Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/17/2024 MGI 6.24 |
|
|