Sequence Detail

ID/Version

O35099 Q14AY5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 5; EC=2.7.11.25 {ECO:0000269|PubMed:16648474};AltName: Full=Apoptosis signal-regulating kinase 1; Short=ASK-1;AltName: Full=MAPK/ERK kinase kinase 5; Short=MEK kinase 5;

Provider

SWISS-PROT

Sequence

Polypeptide 1380 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k5	mitogen-activated protein kinase kinase kinase 5	80	114	3	12

Sequence references in MGI

J:44039 Tobiume K, et al., Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun. 1997 Oct 29;239(3):905-10
J:88612 Tobiume K, et al., ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001 Mar;2(3):222-8
J:98954 Matsuzawa A, et al., ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol. 2005 Jun;6(6):587-92
J:109068 Liu Q, et al., Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol Cell Biol. 2006 May;26(10):3785-97
J:125559 Saito J, et al., Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon. Biochem J. 2007 Aug 1;405(3):591-6
J:135681 Rubiolo C, et al., A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood. 2006 Jul 1;108(1):152-9
J:143783 Jung H, et al., Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J Biol Chem. 2008 Dec 12;283(50):34541-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89