Sequence Detail

ID/Version

O70161 Q505A1 Q80TW9 Q8VCU5 (UniProt | EBI)

Last sequence update: 2005-10-25
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma {ECO:0000305|PubMed:9535851}; Short=PIP5K1-gamma {ECO:0000305|PubMed:9535851}; Short=PtdIns(4)P-5-kinase 1 gamma {ECO:0000305|PubMed:9535851}; EC=2.7.1.68 {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 661 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma	39	110	4	18

Sequence references in MGI

J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:88885 Giudici ML, et al., A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma. Biochem J. 2004 Apr 15;379(Pt 2):489-96
J:92666 Di Paolo G, et al., Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature. 2004 Sep 23;431(7007):415-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114866 Bairstow SF, et al., Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. J Biol Chem. 2006 Jul 21;281(29):20632-42
J:131432 Wang Y, et al., PIP5KI gamma is required for cardiovascular and neuronal development. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11748-53
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:146157 Mao YS, et al., Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol. 2009 Jan 26;184(2):281-96
J:149741 Thieman JR, et al., Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage. J Biol Chem. 2009 May 15;284(20):13924-39
J:164732 Wernimont SA, et al., PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23
J:166299 Volpicelli-Daley LA, et al., Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 2010 Sep 10;285(37):28708-14
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297318 Shulga YV, et al., Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. J Biol Chem. 2012 Oct 19;287(43):35953-63
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87