Sequence Detail

ID/Version

O70628 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A {ECO:0000305}; EC=3.1.4.35 {ECO:0000269|PubMed:9624145};

Provider

SWISS-PROT

Sequence

Polypeptide 534 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pde9a	phosphodiesterase 9A	30	105	5	25

Sequence references in MGI

J:48139 Soderling SH, et al., Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem. 1998 Jun 19;273(25):15553-8
J:51539 Guipponi M, et al., Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence. Hum Genet. 1998 Oct;103(4):386-92
J:214856 Kroker KS, et al., PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition. Neurobiol Aging. 2014 Sep;35(9):2072-8
J:220465 Lee DI, et al., Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26;519(7544):472-6