ID/Version |
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Sequence description from provider |
RecName: Full=Sortilin-related receptor;AltName: Full=Gp250;AltName: Full=Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Short=LDLR relative with 11 ligand-binding repeats; Short=LR11 {ECO:0000303|PubMed:9726247} | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
2215
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
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Sequence references in MGI |
J:46143
Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
J:49561 Kanaki T, et al., Developmental regulation of LR11 expression in murine brain. DNA Cell Biol. 1998 Aug;17(8):647-57 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:101417 Andersen OM, et al., Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6 J:104263 Spoelgen R, et al., Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci. 2006 Jan 11;26(2):418-28 J:156182 Rohe M, et al., Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci. 2009 Dec 9;29(49):15472-8 J:162573 Reiche J, et al., SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol. 2010 Jun;30(12):3027-37 J:196326 Glerup S, et al., SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET. Cell Rep. 2013 Jan 31;3(1):186-99 J:205834 Rohe M, et al., SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PLoS One. 2013;8(8):e72164 J:228024 Whittle AJ, et al., Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015;6:8951 J:237133 Schmidt V, et al., SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest. 2016 Jul 01;126(7):2706-20 J:243857 Larsen JV, et al., SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 Jun 01;37(11) J:276421 Geng Z, et al., Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor. J Biol Chem. 2011 Dec 2;286(48):41871-82 J:285223 Hampe W, et al., Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator. J Cell Sci. 2000 Dec;113 Pt 24:4475-85 J:287209 Madsen P, et al., HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA. Sci Rep. 2019 Jan 24;9(1):611 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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