Sequence Detail

ID/Version

O88307 O54711 Q3UHM3 O70581 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Sortilin-related receptor;AltName: Full=Gp250;AltName: Full=Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Short=LDLR relative with 11 ligand-binding repeats; Short=LR11 {ECO:0000303|PubMed:9726247}

Provider

SWISS-PROT

Sequence

Polypeptide 2215 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	116	118	3	24

Sequence references in MGI

J:46143 Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
J:49561 Kanaki T, et al., Developmental regulation of LR11 expression in murine brain. DNA Cell Biol. 1998 Aug;17(8):647-57
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101417 Andersen OM, et al., Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6
J:104263 Spoelgen R, et al., Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci. 2006 Jan 11;26(2):418-28
J:156182 Rohe M, et al., Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci. 2009 Dec 9;29(49):15472-8
J:162573 Reiche J, et al., SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol. 2010 Jun;30(12):3027-37
J:196326 Glerup S, et al., SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET. Cell Rep. 2013 Jan 31;3(1):186-99
J:205834 Rohe M, et al., SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PLoS One. 2013;8(8):e72164
J:228024 Whittle AJ, et al., Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015;6:8951
J:237133 Schmidt V, et al., SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest. 2016 Jul 01;126(7):2706-20
J:243857 Larsen JV, et al., SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 Jun 01;37(11)
J:276421 Geng Z, et al., Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor. J Biol Chem. 2011 Dec 2;286(48):41871-82
J:285223 Hampe W, et al., Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator. J Cell Sci. 2000 Dec;113 Pt 24:4475-85
J:287209 Madsen P, et al., HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA. Sci Rep. 2019 Jan 24;9(1):611
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89