Sequence Detail

ID/Version

O88444 Q5SS89 (UniProt | EBI)

Last sequence update: 2005-04-12
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Adenylate cyclase type 1; EC=4.6.1.1 {ECO:0000269|PubMed:9662407};AltName: Full=ATP pyrophosphate-lyase 1;AltName: Full=Adenylate cyclase type I;AltName: Full=Adenylyl cyclase 1;AltName: Full=Ca(2+)/calmodulin-activated adenylyl cycl

Provider

SWISS-PROT

Sequence

Polypeptide 1118 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adcy1	adenylate cyclase 1	45	110	4	12

Sequence references in MGI

J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
J:48517 Abdel-Majid RM, et al., Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nat Genet. 1998 Jul;19(3):289-91
J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
J:213883 Santos-Cortez RL, et al., Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish. Hum Mol Genet. 2014 Jun 15;23(12):3289-98
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89