Sequence Detail

ID/Version

O88870 B2RSY6 Q6H1V0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Bestrophin-1 {ECO:0000250|UniProtKB:O76090};AltName: Full=Vitelliform macular dystrophy protein 2 homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 551 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Best1	bestrophin 1	31	99	3	8

Sequence references in MGI

J:57560 Petrukhin K, et al., Identification of the gene responsible for Best macular dystrophy. Nat Genet. 1998 Jul;19(3):241-7
J:107882 Kramer F, et al., Cloning and characterization of the murine Vmd2 RFP-TM gene family. Cytogenet Genome Res. 2004;105(1):107-14
J:165844 Lee S, et al., Channel-mediated tonic GABA release from glia. Science. 2010 Nov 5;330(6005):790-6
J:188266 Woo DH, et al., TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation. Cell. 2012 Sep 28;151(1):25-40
J:319401 Oh SJ, et al., Direct interaction with 14-3-3gamma promotes surface expression of Best1 channel in astrocyte. Mol Brain. 2017 Nov 9;10(1):51
J:345001 Park H, et al., Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain. 2015 Feb 3;8:7