ID/Version |
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Sequence description from provider |
RecName: Full=BDNF/NT-3 growth factors receptor; EC=2.7.10.1 {ECO:0000269|PubMed:27457814};AltName: Full=GP145-TrkB/GP95-TrkB; Short=Trk-B;AltName: Full=Neurotrophic tyrosine kinase receptor type 2;AltName: Full=TrkB tyrosine kinase;Flags: | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
821
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:10104
Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
J:40431 Ninkina N, et al., TrkB variants with deletions in the leucine-rich motifs of the extracellular domain. J Biol Chem. 1997 May 16;272(20):13019-25 J:41358 Klein R, et al., The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 1990 May 18;61(4):647-56 J:41382 Soppet D, et al., The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 1991 May 31;65(5):895-903 J:49434 Farinas I, et al., Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998 Aug;21(2):325-34 J:56847 Klein R, et al., Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 1993 Oct 8;75(1):113-22 J:58229 Minichiello L, et al., Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999 Oct;24(2):401-14 J:86332 Du J, et al., Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol. 2003 Oct 27;163(2):385-95 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37 J:132562 Medina DL, et al., TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J. 2004 Oct 1;23(19):3803-14 J:169866 Chen AI, et al., TrkB (Tropomyosin-Related Kinase B) Controls the Assembly and Maintenance of GABAergic Synapses in the Cerebellar Cortex. J Neurosci. 2011 Feb 23;31(8):2769-80 J:180470 Miyamoto Y, et al., TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9 J:180478 Douma S, et al., Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 2004 Aug 26;430(7003):1034-9 J:180482 Rose CR, et al., Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 2003 Nov 6;426(6962):74-8 J:199564 Baeza-Raja B, et al., p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34 J:205834 Rohe M, et al., SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PLoS One. 2013;8(8):e72164 J:239200 Fu X, et al., Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Mol Biol Cell. 2011 Oct;22(19):3684-98 J:274852 Glerup S, et al., SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry. 2016 Dec;21(12):1740-1751 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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