Sequence Detail

ID/Version

P21274 Q497W8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Bone morphogenetic protein 2; Short=BMP-2;AltName: Full=Bone morphogenetic protein 2A; Short=BMP-2A;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 394 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bmp2	bone morphogenetic protein 2	207	278	4	19

Sequence references in MGI

J:10440 Dickinson ME, et al., Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 1990 Mar;6(3):505-20
J:18993 Feng JQ, et al., Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. Biochim Biophys Acta. 1994 Jun 21;1218(2):221-4
J:86665 Laurikkala J, et al., Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol. 2003 Dec 1;264(1):91-105
J:98740 Samad TA, et al., DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Apr 8;280(14):14122-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101046 Babitt JL, et al., Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Aug 19;280(33):29820-7
J:109016 Babitt JL, et al., Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May;38(5):531-9
J:117670 Sudo S, et al., Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 2004 May 28;279(22):23134-41
J:123381 Xia Y, et al., Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22;282(25):18129-40
J:124617 Yamada S, et al., PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization. J Biol Chem. 2007 Aug 10;282(32):23070-80
J:203960 Combs MD, et al., Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J Biol Chem. 2013 Oct 4;288(40):28869-80
J:258535 Tan TY, et al., Monoallelic BMP2 Variants Predicted to Result in Haploinsufficiency Cause Craniofacial, Skeletal, and Cardiac Features Overlapping Those of 20p12 Deletions. Am J Hum Genet. 2017 Dec 7;101(6):985-994
J:335613 Wang CY, et al., Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type Ireceptor ALK3. Blood. 2020;135(6):453-456
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:341424 Feng XY, et al., Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. Eur J Oral Sci. 2013 Oct;121(5):412-20