Sequence Detail

ID/Version

P40645 Q9QWS5 Q62250 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Transcription factor SOX-6 {ECO:0000305};AltName: Full=SOX-LZ {ECO:0000303|PubMed:10996314};

Provider

SWISS-PROT

Sequence

Polypeptide 827 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sox6	SRY (sex determining region Y)-box 6	73	149	3	18

Sequence references in MGI

J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
J:26205 Takamatsu N, et al., A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein. Mol Cell Biol. 1995 Jul;15(7):3759-66
J:28919 Connor F, et al., The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucleic Acids Res. 1995 Sep 11;23(17):3365-72
J:50394 Lefebvre V, et al., A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998 Oct 1;17(19):5718-33
J:64789 Yamashita A, et al., Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. FEBS Lett. 2000 Sep 15;481(2):147-51
J:79879 Akiyama H, et al., The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
J:80666 Smits P, et al., The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
J:86174 Cohen-Barak O, et al., Sox6 regulation of cardiac myocyte development. Nucleic Acids Res. 2003 Oct 15;31(20):5941-8
J:88817 Smits P, et al., Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58
J:231103 Baroti T, et al., Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016 Jan;136(2):316-28
J:233055 Liu CF, et al., The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res. 2015 Sep 30;43(17):8183-203
J:237490 Brunmeir R, et al., Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474
J:287044 Ikeda T, et al., The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum. 2004 Nov;50(11):3561-73
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89