ID/Version |
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Sequence description from provider |
RecName: Full=Tyrosine-protein kinase SYK; EC=2.7.10.2;AltName: Full=Spleen tyrosine kinase; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
629
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:27983
Fluck M, et al., Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein. Biochem Biophys Res Commun. 1995 Aug 4;213(1):273-81
J:29796 Turner M, et al., Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995 Nov 16;378(6554):298-302 J:29797 Cheng AM, et al., Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 1995 Nov 16;378(6554):303-6 J:40327 Poole A, et al., The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 1997 May 1;16(9):2333-41 J:90684 Ohtsuka M, et al., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8126-31 J:97989 Rogers NC, et al., Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005 Apr;22(4):507-17 J:110529 Vines CM, et al., Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct;15(4):507-19 J:111210 Abtahian F, et al., Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science. 2003 Jan 10;299(5604):247-51 J:116120 Mocsai A, et al., Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006 Dec;7(12):1326-33 J:119368 Underhill DM, et al., Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood. 2005 Oct 1;106(7):2543-50 J:120084 Zou W, et al., Syk, c-Src, the alpha v beta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12;176(6):877-88 J:120692 Sohn HW, et al., Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med. 2003 Jun 2;197(11):1511-24 J:126630 Suzuki-Inoue K, et al., A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. 2006 Jan 15;107(2):542-9 J:129191 Yu M, et al., Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol. 2006 Feb 15;176(4):2421-9 J:143491 Oda H, et al., RhoH plays critical roles in FcepsilonRI-dependent signal transduction in mast cells. J Immunol. 2009 Jan 15;182(2):957-62 J:144525 Hida S, et al., Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 2009 Feb;10(2):214-22 J:147472 Sancho D, et al., Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009 Apr 16;458(7240):899-903 J:148538 Gross O, et al., Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature. 2009 May 21;459(7245):433-6 J:155479 Van Ziffle JA, et al., Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26;114(23):4871-82 J:180490 Obergfell A, et al., Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15;157(2):265-75 J:195394 Lu R, et al., CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8(4):e1002597 J:226057 Murata Y, et al., Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4264-71 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:305203 Wang L, et al., Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet. 2021 Apr;53(4):500-510 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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