ID/Version |
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Sequence description from provider |
RecName: Full=Ephrin type-B receptor 2 {ECO:0000305}; EC=2.7.10.1;AltName: Full=Neural kinase;AltName: Full=Nuk receptor tyrosine kinase;AltName: Full=Tyrosine-protein kinase receptor EPH-3;AltName: Full=Tyrosine-protein kinase receptor SEK-3;Cont | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
986
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:19646
Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
J:31706 Henkemeyer M, et al., Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene. 1994 Apr;9(4):1001-14 J:34200 Henkemeyer M, et al., Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996 Jul 12;86(1):35-46 J:37095 Orioli D, et al., Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49 J:51893 Torres R, et al., PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998 Dec;21(6):1453-63 J:53085 Adams RH, et al., Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999 Feb 1;13(3):295-306 J:58260 Dodelet VC, et al., A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem. 1999 Nov 5;274(45):31941-6 J:60835 Imondi R, et al., Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000 Apr;127(7):1397-410 J:62565 Cowan CA, et al., EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000 May;26(2):417-30 J:73356 Himanen JP, et al., Crystal structure of an Eph receptor-ephrin complex. Nature. 2001 Dec 20-27;414(6866):933-8 J:87071 Henkemeyer M, et al., Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol. 2003 Dec 22;163(6):1313-26 J:91491 Dravis C, et al., Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004 Jul 15;271(2):272-90 J:116249 Himanen JP, et al., Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci. 2004 May;7(5):501-9 J:122772 Litterst C, et al., Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem. 2007 Jun 1;282(22):16155-63 J:167914 Margolis SS, et al., EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29;143(3):442-55 J:241039 Alonso-Martin S, et al., Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis. Front Cell Dev Biol. 2016;4:58 J:266463 Okumura F, et al., Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol Biol Cell. 2017 Nov 15;28(24):3532-3541 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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