Sequence Detail

ID/Version

P56581 Q8BPK0 Q5U3M5 Q542A9 Q3TPW4 Q6PJW4 Q5U3M4 (UniProt | EBI)

Last sequence update: 2013-05-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=G/T mismatch-specific thymine DNA glycosylase; EC=3.2.2.29;AltName: Full=C-JUN leucine zipper interactive protein JZA-3;AltName: Full=Thymine-DNA glycosylase;

Provider

SWISS-PROT

Sequence

Polypeptide 421 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tdg	thymine DNA glycosylase	55	98	4	13

Sequence references in MGI

J:33282 Chevray PM, et al., Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5789-93
J:52013 Um S, et al., Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. J Biol Chem. 1998 Aug 14;273(33):20728-36
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:174772 Cortellino S, et al., Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 8;146(1):67-79
J:175857 He YF, et al., Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science. 2011 Sep 2;333(6047):1303-7
J:196259 Cortazar D, et al., Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature. 2011 Feb 17;470(7334):419-23