ID/Version |
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Sequence description from provider |
RecName: Full=Caspase-3; Short=CASP-3; EC=3.4.22.56 {ECO:0000269|PubMed:12124386, ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:33725486};AltName: Full=Apopain;AltName: Full=Cysteine protease CPP32 {ECO:0000303|PubMed:8934524}; S | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
277
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:34911
Juan TS, et al., Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene. 1996 Aug 15;13(4):749-55
J:36821 Kuida K, et al., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996 Nov 28;384(6607):368-72 J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9 J:38625 Mukasa T, et al., Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF. Biochem Biophys Res Commun. 1997 Feb 24;231(3):770-4 J:79113 Xu J, et al., The role of Asp-462 in regulating Akt activity. J Biol Chem. 2002 Sep 20;277(38):35561-6 J:105496 Lakhani SA, et al., Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science. 2006 Feb 10;311(5762):847-51 J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30 J:274136 Ning X, et al., Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. Mol Cell. 2019 Apr 4;74(1):19-31.e7 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:305632 Maruoka M, et al., Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Mol Cell. 2021 Apr 1;81(7):1397-1410.e9 J:306586 Suzuki J, et al., Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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