ID/Version |
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Sequence description from provider |
RecName: Full=Chromobox protein homolog 1;AltName: Full=Heterochromatin protein 1 homolog beta; Short=HP1 beta;AltName: Full=Heterochromatin protein p25;AltName: Full=M31;AltName: Full=Modifier 1 protein; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
185
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:32398
Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15 J:40326 Ball LJ, et al., Structure of the chromatin binding (chromo) domain from mouse modifier protein 1. EMBO J. 1997 May 1;16(9):2473-81 J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38 J:58506 Nielsen AL, et al., Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 1999 Nov 15;18(22):6385-95 J:61443 Brasher SV, et al., The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J. 2000 Apr 3;19(7):1587-97 J:88277 Thiru A, et al., Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J. 2004 Feb 11;23(3):489-99 J:90491 Schotta G, et al., A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:106935 Davis CA, et al., PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36 J:114031 Lachner M, et al., Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001 Mar 1;410(6824):116-20 J:175104 Nielsen PR, et al., Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002 Mar 7;416(6876):103-7 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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