Sequence Detail

ID/Version

P83917 P23197 (UniProt | EBI)

Last sequence update: 2004-06-07
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Chromobox protein homolog 1;AltName: Full=Heterochromatin protein 1 homolog beta; Short=HP1 beta;AltName: Full=Heterochromatin protein p25;AltName: Full=M31;AltName: Full=Modifier 1 protein;

Provider

SWISS-PROT

Sequence

Polypeptide 185 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cbx1	chromobox 1	42	109	4	238

Sequence references in MGI

J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
J:40326 Ball LJ, et al., Structure of the chromatin binding (chromo) domain from mouse modifier protein 1. EMBO J. 1997 May 1;16(9):2473-81
J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
J:58506 Nielsen AL, et al., Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 1999 Nov 15;18(22):6385-95
J:61443 Brasher SV, et al., The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J. 2000 Apr 3;19(7):1587-97
J:88277 Thiru A, et al., Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J. 2004 Feb 11;23(3):489-99
J:90491 Schotta G, et al., A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106935 Davis CA, et al., PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36
J:114031 Lachner M, et al., Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001 Mar 1;410(6824):116-20
J:175104 Nielsen PR, et al., Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002 Mar 7;416(6876):103-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89