ID/Version |
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Sequence description from provider |
RecName: Full=Adenylate cyclase type 6; EC=4.6.1.1 {ECO:0000269|PubMed:1379717, ECO:0000269|PubMed:18071070, ECO:0000269|PubMed:20466003, ECO:0000269|PubMed:20864687, ECO:0000269|PubMed:23753526, ECO:0000269|PubMed:24363043};AltName: Full=ATP pyro | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1165
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:1747
Yoshimura M, et al., Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6716-20
J:36274 Premont RT, et al., Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation. Endocrinology. 1992 Dec;131(6):2774-84 J:122415 Michalski N, et al., Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007 Jun 13;27(24):6478-88 J:143138 Tang T, et al., Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 1;117(1):61-9 J:161317 Chien CL, et al., Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6). FEBS Lett. 2010 Jul 2;584(13):2883-90 J:162338 Kwon RY, et al., Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J. 2010 Aug;24(8):2859-68 J:173554 Choi YH, et al., Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84 J:185899 Rieg T, et al., Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec;21(12):2059-68 J:210708 Lee KL, et al., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar;28(3):1157-65 J:212781 Sabbatini ME, et al., Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation. J Physiol. 2013 Aug 1;591(Pt 15):3693-707 J:244482 Tang T, et al., Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 06;55(14):1476-86 J:244672 Rees S, et al., Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease. J Am Soc Nephrol. 2014 Feb;25(2):232-7 J:244742 Fenton RA, et al., Renal phosphate wasting in the absence of adenylyl cyclase 6. J Am Soc Nephrol. 2014 Dec;25(12):2822-34 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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