Sequence Detail

ID/Version

Q01887 Q61890 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Tyrosine-protein kinase RYK; EC=2.7.10.1;AltName: Full=Kinase VIK;AltName: Full=Met-related kinase;AltName: Full=NYK-R;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 594 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ryk	receptor-like tyrosine kinase	57	111	3	11

Sequence references in MGI

J:3702 Kelman Z, et al., The murine vik gene (chromosome 9) encodes a putative receptor with unique protein kinase motifs. Oncogene. 1993 Jan;8(1):37-44
J:19807 Hovens CM, et al., RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11818-22
J:21655 Yee K, et al., Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors. Blood. 1993 Aug 15;82(4):1335-43
J:21813 Paul SR, et al., Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met. Int J Cell Cloning. 1992 Sep;10(5):309-14
J:22530 Simoneaux DK, et al., The receptor tyrosine kinase-related gene (ryk) demonstrates lineage and stage-specific expression in hematopoietic cells. J Immunol. 1995 Feb 1;154(3):1157-66
J:93897 Lu W, et al., Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004 Oct 1;119(1):97-108
J:109038 Keeble TR, et al., The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci. 2006 May 24;26(21):5840-8
J:142801 Lyu J, et al., Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell. 2008 Nov;15(5):773-80
J:168206 Liu Y, et al., Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005 Sep;8(9):1151-9