ID/Version |
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Sequence description from provider |
RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; EC=2.7.11.1;AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Short=eIF-2A protein kinase 2;AltName: Full=Interferon-inducible RNA-depen | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
515
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:20201
Tanaka H, et al., Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7995-9
J:23306 Tanaka H, et al., Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. Gene. 1995 Feb 14;153(2):283-4 J:34580 Feng GS, et al., Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5447-51 J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:167126 Harashima A, et al., Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. Genes Dev. 2010 Dec 1;24(23):2640-53 J:186690 Lu B, et al., Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30;488(7413):670-4 J:187314 Irving AT, et al., Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity. 2012 May 25;36(5):795-806 J:192911 Carvalho-Filho MA, et al., Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology. 2012 Nov;153(11):5261-74 J:194275 Stern E, et al., Blocking the eIF2alpha kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. J Neurosci. 2013 Feb 6;33(6):2517-25 J:196116 Pang Q, et al., Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J Biol Chem. 2003 Oct 24;278(43):41709-17 J:196269 Minor RA, et al., Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. J Interferon Cytokine Res. 2010 Apr;30(4):263-72 J:196300 Liu X, et al., PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells. Blood. 2013 Apr 25;121(17):3364-74 J:198044 He Y, et al., The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol. 2013 Apr;43(5):1147-52 J:243779 Nakayama Y, et al., Role of PKR and Type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 2010 Jun 24;6(6):e1000966 J:244722 Thakur SA, et al., Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection. Clin Vaccine Immunol. 2011 Dec;18(12):2060-6 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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