Sequence Detail

ID/Version

Q3UQ28 A4FU83 E9QNQ9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Peroxidasin homolog {ECO:0000305}; EC=1.11.2.- {ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:29626421, ECO:0000269|PubMed:32571911, ECO:0000269|PubMed:32675287};Contains: RecName: Full=PXDN active fragment {ECO:0000250|UniProtKB:

Provider

SWISS-PROT

Sequence

Polypeptide 1475 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pxdn	peroxidasin	48	103	2	5

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143398 Homma S, et al., Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns. 2009 Jan;9(1):1-26
J:143576 Cheng G, et al., Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med. 2008 Dec 15;45(12):1682-94
J:150789 Peterfi Z, et al., Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney. Am J Pathol. 2009 Aug;175(2):725-35
J:213336 Yan X, et al., Peroxidasin is essential for eye development in the mouse. Hum Mol Genet. 2014 Nov 1;23(21):5597-614
J:255314 Bhave G, et al., The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F596-F602
J:255484 Lazar E, et al., Structure-function analysis of peroxidasin provides insight into the mechanism of collagen IV crosslinking. Free Radic Biol Med. 2015 Jun;83:273-82
J:285990 Kim HK, et al., Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation. Int J Mol Sci. 2019 Dec 5;20(24):6144
J:291034 He C, et al., Peroxidasin-mediated bromine enrichment of basement membranes. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15827-15836
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320269 Bhave G, et al., Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Nat Chem Biol. 2012 Sep;8(9):784-90