ID/Version |
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Sequence description from provider |
RecName: Full=Tyrosine-protein kinase JAK2 {ECO:0000305}; EC=2.7.10.2 {ECO:0000269|PubMed:20304997, ECO:0000269|PubMed:21726629};AltName: Full=Janus kinase 2; Short=JAK-2; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1132
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:15255
Silvennoinen O, et al., Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8429-33
J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74 J:25950 Zhao Y, et al., The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. J Biol Chem. 1995 Jun 9;270(23):13814-8 J:40444 Witthuhn BA, et al., JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 1993 Jul 30;74(2):227-36 J:42354 Wilks AF, Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1603-7 J:47298 Neubauer H, et al., Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998 May 1;93(3):397-409 J:47299 Parganas E, et al., Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95 J:124086 Li Z, et al., SH2B1 Enhances Leptin Signaling by Both Janus Kinase 2 Tyr813 Phosphorylation-Dependent and -Independent Mechanisms. Mol Endocrinol. 2007 Sep;21(9):2270-81 J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54 J:157074 Guilluy C, et al., The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010 Feb;16(2):183-90 J:161170 Argetsinger LS, et al., Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol Endocrinol. 2010 May;24(5):1062-76 J:170821 Berry DC, et al., Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4340-5 J:190278 Jakel H, et al., Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene. 2011 Aug 11;30(32):3502-12 J:200427 Funakoshi-Tago M, et al., Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J. 2006 Oct 18;25(20):4763-72 J:200437 Hu J, et al., Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. J Mol Biol. 2006 Aug 4;361(1):69-79 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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